Creative Biogene is a professional biotechnology company in CRISPR editing field. We have developed a mature CRISPR platform for editing microorganisms' genome with a wide range of microbe species. As a pioneer in this field, Creative Biogene could provide you the best service with very short turnaround time and the most competitive price.

Creative Biogene could provide you microbe genome editing services based on our CRISPR platform, which including gene knockout, site-directed mutation, gene knock-in, and so on.

Found in bacteria and archaebacteria, the regular cluster-interval short palindromic repeat (CRISPR) can effectively resist the invasion and insertion of phage and various gene elements at the gene level. CRISPR-Associate (Cas) protein is a kind of RNA-mediated double-stranded DNA endonuclease which own the ability to cleave exogenous DNA. When the conserved spacer proto-adjacent motif (PAM) is present in the invading DNA sequence, the target DNA sequence will be cleaved in the spacer sequence upstream (4-5nt) of the PAM. Because CRISPR-Cas9 system requires only one single Cas9 endonuclease to complete the reaction, and the system is flexible, simple, specific and low cytotoxicity. It has become a popular genome editing technology and widely used in genome engineering.