Messenger RNA (mRNA) is responsible for transferring genetic information from DNA to proteins. With advances in in vitro transcription (IVT) technology, it has been possible to synthesize mRNA from either plasmid-based DNA templates or DNA PCR amplified from plasmids. mRNA synthesized by IVT methods could be sequence optimized to improve efficiency of translation as well as chemically modified to reduce immunogenicity and increase mRNA stability. In addition, synthetic mRNA also has some other advantages, e.g., the lack of risk of gene integration, directly translated into target proteins without the need to enter the nucleus and transient protein expression. All these features make synthetic mRNA as a powerful alternative gene expression system for various applications, including gene editing, cell reprogramming, and the treatment for infectious diseases, cancer, genetic diseases, and so on.

IntegrateRNA, a global biotechnology company specializing in RNA research, can provide a variety of high-quality kits and raw materials for customers worldwide to help your mRNA synthesis.