Self-amplifying RNA (saRNA) has many structural similarities to conventional mRNA: it is a linear, single-stranded RNA molecule that is synthesized with a 5' cap, 3' polyA tail, and 5' and 3' untranslated regions (UTRs). The main structural difference is that saRNA is a much larger molecule as it encodes four extra proteins in addition to the protein of interest or vaccine antigen. SaRNAs...
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