Creative Biogene is offering a comprehensive screen of cellular and biochemical nuclear receptor assays to profile your compounds. Measurements of ligand binding activity, NRs translocation, and NR-coregulator interaction are included to characterize the selectivity and potential off-target events. With our extraordinary experience in drug discovery programs targeting nuclear receptors, our...
Nuclear receptors (NRs) are a class of proteins responsible for thyroid hormones and sensing steroid and certain other molecules. There are 48 genes in the human genome that code for the NRs. As the largest family of eukaryotic transcription factors, NRs control numerous processes involved in development, cell cycle, and important metabolic pathways. Generally, they activate the transcription...
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