Genotoxicity refers to the harmful effects that certain substances can have on the genetic material within a cell. These effects can lead to mutations, cancer, and various other health problems. Therefore, assessing the genotoxic potential of compounds is critical in drug development, environmental safety, and regulatory compliance. Genotoxicity assay kits have emerged as essential tools for...
In the realm of pharmacology and drug development, understanding how a drug permeates biological membranes is crucial. In Vitro Permeability Assay Kits have emerged as vital tools for researchers to evaluate the permeability characteristics of various compounds across biological barriers. These kits are designed to mimic the physiological conditions present in the human body, thereby providing...
Primary human neurons are essential components in the study of the human nervous system, playing a pivotal role in advancing our understanding of neuronal development, function, and pathology. Unlike immortalized cell lines, primary human neurons are derived directly from human sources, showcasing authentic cellular characteristics that are vital for accurate research outcomes.
Isolating...
Reproductive toxicology is one of the most complicated areas of toxicology research due to the involvement of multiple organs and tissues, different modes of toxicant action and dependence on the endocrine system. In particular, endocrine disrupters represent a significant challenge for experimental toxicology because of their complex effects on signal networks and programming. A variety...
Animal studies are the gold standard for preclinical and translational studies of gastrointestinal (GI) disease. Although there are now specialized cell lines and "organs-on-a-chip" that provide in vitro platforms that can be used for drug selectivity and specificity studies, only whole-animal physiology can approximate clinical pathology and the effects of novel therapeutics....
High content screening (HCS), also known as automated microscope-based screening, measures the biological activity of a single cell or a whole organism after treatment with thousands of agents in a multi-well plate. Typically, the cell or organism are characterized by one or more fluorescent dyes, which leads to the term "high content".
Cell-based HCS has rapidly gained attention, as it is...
Creative Bioarray is an experienced and outstanding provider of cell-based Screening and profiling Services including cell-based high-throughput and high-content screening, specificity and selectivity profiling, and dose-response analysis. With our experienced scientific team and advanced technologies, we are able to quickly narrow down a large pool of candidates and identify effective...
In research labs worldwide, the study of gene expression and its impact on various biological processes is crucial in unlocking the mysteries of diseases and finding potential treatments. At our Gene Overexpression Cell Line Construction Service, we understand the importance of having reliable and efficient tools to manipulate gene expression for research purposes. Our service offers...
As a biology researcher, staying at the cutting edge of technology is crucial to advancing research in the field. The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. However, the monitoring and detection of CAR-T cells in vivo remain a challenge in the evaluation...
Research on the distribution of radiolabeled test compounds in animals is an important part of many companies' preclinical drug development programs. The data obtained from these studies generally form the basis for evaluating the exposure of human organs and tissues to the test compound and the removal of residues/metabolites from those organs and tissues after drug administration. The data...
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