Animal studies are the gold standard for preclinical and translational studies of gastrointestinal (GI) disease. Although there are now specialized cell lines and "organs-on-a-chip" that provide in vitro platforms that can be used for drug selectivity and specificity studies, only whole-animal physiology can approximate clinical pathology and the effects of novel therapeutics.

Creative Bioarray has extensive experience in GI studies for a variety of indications. Our expertise in GI preclinical research and consistent track record of success as a full-service CRO ensures the flexibility to adapt to the unique needs of each trial. Our disease models are suitable for testing disease-modifying drug or compounds acting on symptomatic effects. Depending on your needs, it is possible to perform classical, oral (PO), intravenous (IV), intraperitoneal (IP) or intrarectal administration.

Irritable Bowel Syndrome (IBS)

• Water avoidance stress (WAS)-induced colonic hypersensitivity
• Restraint stress-induced colonic hypersensitivity
• Brain or spinal cord manipulation-induced colonic hypersensitivity
• Acetic acid or butyrate enema-induced colonic hypersensitivity
• Capsaicin-, mustard oil-, or zymosan-induced inflammatory colonic hypersensitivity
• Post-inflammatory colonic hypersensitivity

Inflammatory Bowel Disease (IBD)

• Dextran sodium sulfate (DSS)-induced colitis
• 2,4,6-Trinitrobenzene sulfonic acid (TNBS)-induced colitis
• Indomethacin-induced intestinal inflammation

Ulcer

• Acetic acid-induced ulcer
• Pylorus ligation ulceration models
• HCl/ethanol-induced ulcer
• Restraint stress/cold-restraint stress-induced ulcer
• Acetylsalicylic acid-induced ulcer
• Indomethacin-induced ulcer
• Piroxicam-induced ulcer

Gastroparesis

• Phenol red/blue dextran/methylene blue meal models
• Solid food emptying models
• [¹³C]-octanoic acid breath test models
• Barium meal models
• Plasma acetaminophen models