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- Quantitative Tissue DistributionResearch on the distribution of radiolabeled test compounds in animals is an important part of many companies' preclinical drug development programs. The data obtained from these studies generally form the basis for evaluating the exposure of human organs and tissues to the test compound and the removal of residues/metabolites from those organs and tissues after drug administration. The data...0 Kommentare 0 Anteile 568 AnsichtenPlease log in to like, share and comment!
- Nuclear Receptor Screening ServicesNuclear receptors (NRs) are a class of proteins responsible for thyroid hormones and sensing steroid and certain other molecules. There are 48 genes in the human genome that code for the NRs. As the largest family of eukaryotic transcription factors, NRs control numerous processes involved in development, cell cycle, and important metabolic pathways. Generally, they activate the transcription...0 Kommentare 0 Anteile 539 Ansichten
- Metabolite Profiling and IdentificationThe detection and identification of drug metabolites obtained from both in vitro and in vivo studies in preclinical species is an important part of the discovery process. Ultimately, these studies will lead to a comprehensive description of the metabolism of successful compounds in humans. As a drug discovery program progresses, it becomes more important to know the types of...0 Kommentare 0 Anteile 583 Ansichten
- Telomere Length Analysis (qPCR assay)Telomeres represent the nucleotide repeat sequences at the ends of chromosomes and are important for chromosome stability. They can shorten at each round of DNA replication mainly because of incomplete DNA synthesis of the lagging strand. Reduced relative telomere length is associated with aging and a range of disease states. Creative Bioarray employs qPCR assay to measure...0 Kommentare 0 Anteile 952 Ansichten
- CAR-T/CAR-NK Target Assessment Service (ISH)Chimeric antigen receptor (CAR) T cell therapy is highly effective in treating hematologic malignancies, and major efforts are being made to achieve similar efficacy in solid tumors. Two landmark events occurred for CAR-T cell therapy in 2017: two anti-CD19 CAR-T cells were approved for the therapy of acute lymphoblastic leukemia (ALL) and relapsed or refractory large B-cell lymphoma,...0 Kommentare 0 Anteile 980 Ansichten
- In Situ Detection of CAR-T Cells & Oncolytic VirusesCAR-T cells have yielded unprecedented efficacy in B cell malignancies, most remarkably anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate. The ability to rewire our own immune system to fight cancer has certainly created huge expectations. After the success, more and more preclinical experiments and Phase I-III trials will be...0 Kommentare 0 Anteile 1015 Ansichten
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