Nuclear receptors (NRs) are a class of proteins responsible for thyroid hormones and sensing steroid and certain other molecules. There are 48 genes in the human genome that code for the NRs. As the largest family of eukaryotic transcription factors, NRs control numerous processes involved in development, cell cycle, and important metabolic pathways. Generally, they activate the transcription...

Research on the distribution of radiolabeled test compounds in animals is an important part of many companies' preclinical drug development programs. The data obtained from these studies generally form the basis for evaluating the exposure of human organs and tissues to the test compound and the removal of residues/metabolites from those organs and tissues after drug administration. The data...

Messenger RNA (mRNA) is responsible for transferring genetic information from DNA to proteins. With advances in in vitro transcription (IVT) technology, it has been possible to synthesize mRNA from either plasmid-based DNA templates or DNA PCR amplified from plasmids. mRNA synthesized by IVT methods could be sequence optimized to improve efficiency of translation as well as chemically...

Self-amplifying RNA (saRNA) has many structural similarities to conventional mRNA: it is a linear, single-stranded RNA molecule that is synthesized with a 5' cap, 3' polyA tail, and 5' and 3' untranslated regions (UTRs). The main structural difference is that saRNA is a much larger molecule as it encodes four extra proteins in addition to the protein of interest or vaccine antigen. SaRNAs...

IntegrateRNA uses the most powerful microarray platforms to provide you with the best miRNA expression profiling services that are constantly being validated, tested and updated. We have standard and custom microarrays for all mature miRNAs of all species available in miRBase V21.0 database. Our comprehensive service includes sample control, sample preparation and labeling, microRNA detection,...

Wenn Ihr Ziel darin besteht, eine Website zu entwickeln, die Besucher anzieht und sie in Kunden verwandelt, ist eine attraktive Webdesign-Agentur absolut unerlässlich. Ein großartiges Design sorgt für ein positives Markenerlebnis und hilft, Glaubwürdigkeit zu schaffen, was zu mehr Konversionen und einer besseren Geschäftsleistung führt. Die Schaffung eines solch...

Join the excitement in Monopoly Go!'s latest event, the Laboratory Lift-Off Tournament! Experience the thrill of competition as you compete for amazing rewards in this thrilling tournament. Laboratory Lift-Off participants can accumulate points to reach different milestones, with the final milestone awarding up to 4,255 Dice Rolls. This article provides an in-depth look at the rewards of the...

Embark on a thrilling adventure with Featherweight Games' latest creation, "Auto Pirates: Captains Cup". Engage in strategic battles in this exciting auto-battler game that is currently available for early access in selected regions. Auto Pirates is a competitive strategy game where you choose, equip and battle with your crew for plunder and global rank without pay-to-win. It is friendly to new...

Introduction: The Concerns Surrounding FC 25 As the launch of FC 25 approaches, there is a growing concern among fans regarding the game. This anxiety stems primarily from the unfavorable feedback the FC 25 beta has garnered. Many enthusiasts are apprehensive that the modifications are too minor, leading to worries that FC 25 might just be a slightly upgraded version of FC 24....

New Spiritborn Class Revealed The Diablo 4 team recently hosted a livestream unveiling the exciting new class, Spiritborn, which will accompany the Vessel of Hatred expansion. Key figures from the development team presented the reveal, including: Brent Gibson, Game Director Eleni Rivera-Colon, Associate Narrative Designer Nick...